Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998
| Autor: | Hiroyuki Shimizu, Okuno Y, Kumiko Yoshii, Shih, Wang Gr, Sinniah M, Chang Ks, Hiromu Yoshida, Akio Hagiwara, Chen Hy, Nobuhiko Okabe, Tetsuo Yoneyama, Andi Utama, Chuan-Liang Kao, Tatsuo Miyamura, Yusof Ma |
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| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
Genotype Taiwan Severity of Illness Index Hand-foot-and-mouth disease Disease Outbreaks stomatognathic system Japan medicine Enterovirus 71 Humans Phylogeny DNA Primers Enterovirus Foot-and-mouth disease biology business.industry Reverse Transcriptase Polymerase Chain Reaction Infant Newborn Malaysia Infant General Medicine medicine.disease biology.organism_classification Virology Infectious Diseases business Hand Foot and Mouth Disease |
| Zdroj: | Web of Science Scopus-Elsevier |
| ISSN: | 1344-6304 |
| Popis: | Enterovirus 71 (EV71), one of the major causative agents for hand, foot and mouth disease (HFMD), is sometimes associated with severe central nervous system diseases. In 1997, in Malaysia and Japan, and in 1998 in Taiwan, there were HFMD epidemics involving sudden deaths among young children, and EV71 was isolated from the HFMD patients, including the fatal cases. The nucleotide sequences of each EV71 isolate were determined and compared by phylogenetical analysis. EV71 strains from previously reported epidemics belonged to genotype A-1, while those from recent epidemics could be divided into two genotypes, A-2 and B. In Malaysia, genotype A-2 was more prevalent, while in Japan and Taiwan, B genotype was more prevalent. Two isolates from fatal cases in Malaysia and one isolate from a fatal case in Japan were genotype A-2. However, all isolates from three fatal cases in Taiwan belonged to genotype B. The severity of the HFMD did not link directly to certain genotypes of EV71. |
| Databáze: | OpenAIRE |
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