Mapped Auditory Evoked Potentials Before and After Interferon Treatment
| Autor: | Francesco Marletta, Carmelo Marletta, Trovato Ba, Mariano Malaguarnera, R. Siciliano, Massimo Motta, S Restuccia, Giovanni Pistone |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Irritability Hepatitis C virus Antibody Liver disease Interferon Virology Internal medicine medicine Humans Hepatitis Chronic Hepatitis Brain Mapping business.industry Chronic Active Neurotoxicity Interferon-alpha Cell Biology Hepatitis C Antibodies Middle Aged medicine.disease Hepatitis C Endocrinology Case-Control Studies Anesthesia Evoked Potentials Auditory Female medicine.symptom business Somnolence medicine.drug |
| Zdroj: | Journal of Interferon & Cytokine Research. 16:441-446 |
| ISSN: | 1557-7465 1079-9907 |
| Popis: | Neurotoxicity induced by interferon (IFN) is revealed by neurobehavioral changes, such as irritability, somnolence, lack of motivation, and delayed ideation. As these side effects persist throughout IFN-alpha treatment, we studied cerebral mapped auditory evoked potentials (MAEP) in 20 hepatitis C virus antibody (HCV Ab)-positive chronic active hepatitis patients before and after administration of leukocyte IFN-alpha (i.m. 3,000,000 IU). Some of the main components of MAEP, such as morphology, latency, and power spectra, were altered before IFN injection. These parameters changed 7 h after administration as revealed by increased quality and quantity of acoustic signal reaching the brain cortex and appearance of physiologic waves in patients with mild/intermediate liver disease. These effects revealed 48 h after IFN administration. |
| Databáze: | OpenAIRE |
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