Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica
| Autor: | Amporn Rungrod, Yodhathai Thebtaranonth, Prasat Kittakoop, Maneekarn Chinworrungsee, Morakot Tanticharoen, Masahiko Isaka |
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| Rok vydání: | 2001 |
| Předmět: |
Sesterterpenes
Stereochemistry medicine.drug_class Carboxylic acid Plasmodium falciparum Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Pharmacognosy Antimycobacterial Biochemistry KB Cells Antimalarials Inhibitory Concentration 50 Minimum inhibitory concentration Drug Discovery medicine Animals Humans Mycobacteriaceae Molecular Biology Antibacterial agent chemistry.chemical_classification Terpenes Organic Chemistry Fungi Succinates Biological activity Cytochalasins Ochratoxins Terpenoid Dicarboxylic acid Isocoumarins chemistry Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 11:1965-1969 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)00327-4 |
| Popis: | Three known compounds, 2-hexylidene-3-methylsuccinic acid (1), cytochalasin Q (2), and 5-carboxymellein (3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester (4) and an ophiobolane sesterterpene named halorosellinic acid (5), were isolated from culture broth of the marine fungus Halorosellinia oceanica BCC 5149. Compounds 1-3 exhibited moderate cytotoxicity against KB and BC-1 cell lines with IC(50) values of 1-13 microg/mL, while compounds 2, 3, 5, and 6 showed antimalarial activity with respective IC(50) values of 17, 4, 13, and 19 microg/mL. Halorosellinic acid (5) possessed only weak antimycobacterial activity with the minimum inhibitory concentration of 200 microg/mL. |
| Databáze: | OpenAIRE |
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