Reduced Platelet Aggregation in a Boy with Scurvy
| Autor: | Bernd A. Neubauer, Kemkes-Matthes B, Krombach Ga, Jan-Falco Wilbrand, Dey F, Andreas Hahn, Möller A |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Platelet Aggregation Contusions Developmental Disabilities Gastroenterology Diagnosis Differential Gingivitis Internal medicine Thrombocytopathy Humans Medicine Platelet Autistic Disorder Ascorbic Acid Deficiency Vitamin C deficiency Child Bone pain Purpura Hematoma Vitamin C business.industry Cerebral Palsy Scurvy medicine.disease Pediatrics Perinatology and Child Health Immunology medicine.symptom Gingival Hemorrhage business |
| Zdroj: | Klinische Pädiatrie. 224:448-452 |
| ISSN: | 1439-3824 0300-8630 |
| DOI: | 10.1055/s-0032-1323835 |
| Popis: | Pediatric scurvy is a rare condition characterized by perifollicular petechiae and bruising, hemorrhagic gingivitis and musculoskeletal symptoms, all assumed to be predominantly related to abnormal collagen structure. We report on a 9-year-old autistic boy with vitamin C deficiency due to a highly limited food range presenting with multiple petechiae, gum bleeding and debilitating bone pain, in whom platelet aggregometry revealed a distinctly reduced thrombocyte aggregation, normalizing after vitamin C supplementation. This observation indicates that platelet dysfunction may additionally contribute to the hemorrhagic diathesis in scurvy, and demonstrates that ascorbic acid deficiency should be considered in children with an otherwise unexplained acquired thrombocytopathy. |
| Databáze: | OpenAIRE |
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