The Amino Acid Composition of Protein Fractions from Normal and Abnormal Epidermis**From the Dermatology Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland and the Department of Dermatology, University of Miami School of Medicine, Miami, Florida
| Autor: | Robert G. Crounse, Laura Avogardo, Josephine Lamas, Lem Davis, Simon Rothberg |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty integumentary system Epidermis (botany) Direct evidence macromolecular substances Cell Biology Dermatology Biology medicine.disease Biochemistry Abnormal protein Amino acid Endocrinology Amino acid composition chemistry Internal medicine Psoriasis Keratin medicine Amino acid metabolism Molecular Biology |
| Zdroj: | Journal of Investigative Dermatology. 44:320-325 |
| ISSN: | 0022-202X |
| DOI: | 10.1038/jid.1965.56 |
| Popis: | The postulate that keratinous protein in psoriatic epidermis is abnormal has been the subject of much discussion (1, 2). At present, there is no direct evidence that the disturbed keratinization in psoriasis results in the synthesis of an abnormal protein. Current knowledge indicates that in psoriasis there is an eightfold acceleration of the keratinization process over that found in normal epidermis (3). Whether the faulty fibrillar aggregation (4-7) found in psoriasis is secondary to this acceleration in keratinization or to the synthesis of an abnormal protein is not known. |
| Databáze: | OpenAIRE |
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