Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis
| Autor: | Kazuyoshi Shigehara, Hiroaki Iwamoto, Atsushi Mizokami, Ariunbold Natsagdorj, Kazutaka Narimoto, Kazuaki Machioka, Kouji Izumi, Wen-Jye Lin, Suguru Kadomoto, Aerken Maolake, Yuta Takezawa, Guzailinuer Wufuer, Mikio Namiki |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Receptors CCR4 Receptors CCR2 THP-1 Cells Cell Communication Metastasis 03 medical and health sciences Prostate cancer 0302 clinical medicine Breast cancer Cell Movement Internal medicine medicine Tumor Microenvironment Humans Neoplasm Invasiveness Phosphorylation Protein kinase B Chemokine CCL22 Tumor microenvironment U937 cell business.industry Macrophages Tumor-associated macrophages Cancer Prostatic Neoplasms U937 Cells medicine.disease Coculture Techniques 030104 developmental biology 030220 oncology & carcinogenesis Chemokine CCL17 CCR4 business Proto-Oncogene Proteins c-akt CCL22 CCL2 Research Paper Signal Transduction |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Aerken Maolake 1 , Kouji Izumi 1 , Kazuyoshi Shigehara 1 , Ariunbold Natsagdorj 1 , Hiroaki Iwamoto 1 , Suguru Kadomoto 1 , Yuta Takezawa 1 , Kazuaki Machioka 1 , Kazutaka Narimoto 1 , Mikio Namiki 1 , Wen-Jye Lin 2 , Guzailinuer Wufuer 3 , Atsushi Mizokami 1 1 Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan 2 Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli County, Taiwan 3 Hematology Department of The People’s Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China Correspondence to: Kouji Izumi, email: azuizu2003@yahoo.co.jp Keywords: tumor-associated macrophages, CCL2, prostate cancer, CCL22, CCR4 Received: September 01, 2016 Accepted: November 22, 2016 Published: December 26, 2016 ABSTRACT Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported that TAMs promote prostate cancer metastasis via activation of the CCL2–CCR2 axis. The CCR4 (receptor of CCL17 and CCL22) expression level in breast cancer was reported to be associated with lung metastasis. The aim of this study was to elucidate the role of CCR2 and CCR4 in prostate cancer progression. CCR2 and CCR4 were expressed in human prostate cancer cell lines and prostate cancer tissues. In vitro co-culture of prostate cancer cells and macrophages resulted in increased CCL2 and CCR2 levels in prostate cancer cells. The addition of CCL2 induced CCL22 and CCR4 production in prostate cancer cells. The migration and invasion of prostate cancer cells via enhanced phosphorylation of Akt were promoted by CCL17 and CCL22. CCR4 may be a potential candidate for molecular-targeted therapy. |
| Databáze: | OpenAIRE |
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