Pharmacokinetics of the enantiomers of tertatolol in the rat after oral and intravenous administration
| Autor: | Alexis Gairard, Jean-Claude Koffel, T. Lave, Louis Jung, O. Crambes, B. Van Overloop, C. Efthymiopoulos |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Health Toxicology and Mutagenesis Adrenergic beta-Antagonists Administration Oral Thiophenes Pharmacology Toxicology Biochemistry Gas Chromatography-Mass Spectrometry Propanolamines Pharmacokinetics Oral administration medicine Animals Rats Wistar Volume of distribution Chemistry Stereoisomerism General Medicine Bioavailability Rats Tertatolol Plasma concentration Injections Intravenous Stereoselectivity Enantiomer medicine.drug |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 24(6) |
| ISSN: | 0049-8254 |
| Popis: | 1. Plasma concentrations of the two enantiomers of tertatolol were determined by gc/ms. Deuterium labelling of one of the tertatolol enantiomers was used for chiral discrimination. 2. No isotope effects were observed following simultaneous oral administration of tertatolol and [2H9]tertatolol. 3. After intravenous administration of the pseudoracemate or of each enantiomer separately, (+)-tertatolol showed a lower total clearance and volume of distribution, compared to the (-) enantiomer. 4. After oral administration of the pseudoracemate or of each enantiomer separately, no substantial difference in bioavailability were observed between the enantiomers. |
| Databáze: | OpenAIRE |
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