An integrated model of the gross tumor volume of cervical lymph nodes and pretreatment plasma Epstein–Barr virus DNA predicts survival of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: a big-data intelligence platform-based analysis
| Autor: | Wei-Jie Luo, Yuan Zhang, Ying Sun, Jun Ma, Cheng-Long Huang, Ling-Long Tang, Jun-Yan Li, Yu Pei Chen, Hao Peng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
overall survival lcsh:RC254-282 Virus 03 medical and health sciences 0302 clinical medicine medicine prognostic model distant metastasis-free survival Original Research business.industry nasopharyngeal carcinoma Epstein-Barr virus DNA medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Gross tumor volume 030104 developmental biology medicine.anatomical_structure Oncology Nasopharyngeal carcinoma Cervical lymph nodes 030220 oncology & carcinogenesis Prognostic model Cancer research pretreatment plasma Epstein–Barr virus DNA Intensity modulated radiotherapy Lymph business gross tumor volume of lymph nodes |
| Zdroj: | Therapeutic Advances in Medical Oncology Therapeutic Advances in Medical Oncology, Vol 11 (2019) |
| ISSN: | 1758-8359 1758-8340 |
| Popis: | Background: Few studies have evaluated the prognostic value of the integrated model consisting of gross tumor volume of lymph nodes (GTVnd) and pretreatment plasma Epstein–Barr virus DNA (pre-EBV DNA) in nasopharyngeal carcinoma (NPC) patients. Methods: A well-established big-data intelligence platform with 10,126 NPC patients was used for a retrospective review. A total of 1500 cases with cervical nodal metastases but without distant metastases were randomly assigned to a training ( n = 503) or test condition ( n = 997) for analyses. The cut-off point for the GTVnd derived from the receiver operating characteristic (ROC) curve was combined with the published cut-off point for pre-EBV DNA to develop an integrated model by which patients were classified into four groups. Results: Both GTVnd and pre-EBV DNA were independent prognostic factors. Regardless of whether patients received induction chemotherapy (IC), the 5-year distant metastasis-free survival (DMFS) (69.5%) and overall survival (OS) (68.4%) were significantly worse in those with both a GTVnd >20 ml and pre-EBV DNA >2000 copies/ml (all p-values 20 ml or pre-EBV DNA >2000 copies/ml had the medium 5-year DMFS and OS, while patients with neither of them had the best. Conclusions: The integrated GTVnd and pre-EBV DNA model not only predicted DMFS and OS in NPC patients effectively, but was an indicator of timely adjustment of therapeutic strategies for NPC patients, especially those completing IC. |
| Databáze: | OpenAIRE |
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