Sub-national TB prevalence surveys in India, 2006-2012: Results of uniformly conducted data analysis

Autor: R. Jitendra, Kiran Rade, Ashutosh N. Aggarwal, Suresh K Sharma, D. Baskaran, Paresh Dave, Vineet K. Chadha, V. G. Rao, P. Praseeja, Pratibha Narang, Sharda M. Anjinappa, Kiran Katoch, Soumya Swaminathan, C. Kolappan
Rok vydání: 2019
Předmět:
Bacterial Diseases
Male
Rural Population
0301 basic medicine
Urban Population
Physiology
Pathology and Laboratory Medicine
Geographical Locations
Fluorescence Microscopy
0302 clinical medicine
Medicine and Health Sciences
Coughing
Prevalence
Mass Screening
Medicine
030212 general & internal medicine
Sputum specimen
Geographic Areas
Statistical Data
Microscopy
Multidisciplinary
Geography
Tb control
Statistics
Light Microscopy
Middle Aged
Random effects model
Body Fluids
Actinobacteria
Infectious Diseases
Physical Sciences
Female
Anatomy
medicine.symptom
Research Article
Urban Areas
Adult
Asia
Tuberculosis
Adolescent
Science
030106 microbiology
India
Research and Analysis Methods
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Humans
National level
Tuberculosis
Pulmonary
Setting community
Mass screening
Bacteria
business.industry
Sputum
Organisms
Biology and Life Sciences
Mycobacterium tuberculosis
Tropical Diseases
medicine.disease
Mucus
People and Places
Earth Sciences
Physiological Processes
business
Mathematics
Demography
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 2, p e0212264 (2019)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0212264
Popis: SettingCommunity based tuberculosis (TB) prevalence surveys in ten sites across India during 2006-2012.ObjectiveTo re-analyze data of recent sub-national surveys using uniform statistical methods and obtain a pooled national level estimate of prevalence of TB.MethodsIndividuals ≥15 years old were screened by interview for symptoms suggestive of Pulmonary TB (PTB) and history of anti-TB treatment; additional screening by chest radiography was undertaken in five sites. Two sputum specimens were examined by smear and culture among Screen-positives. Prevalence in each site was estimated after imputing missing values to correct for bias introduced by incompleteness of data. In five sites, prevalence was corrected for non-screening by radiography. Pooled prevalence of bacteriologically positive PTB was estimated using Random Effects Model after excluding data from one site. Overall prevalence of TB (all ages, all types) was estimated by adjusting for extra-pulmonary TB and Pediatric TB.ResultsOf 769290 individuals registered, 715989 were screened by interview and 294532 also by radiography. Sputum specimen were examined from 50 852 individuals. Estimated prevalence of smear positive, culture positive and bacteriologically positive PTB varied between 108.4-428.1, 147.9-429.8 and 170.8-528.4 per 100000 populations in different sites. Pooled estimate of prevalence of bacteriologically positive PTB was 350.0 (260.7, 439.0). Overall prevalence of TB was estimated at 300.7 (223.7-377.5) in 2009, the mid-year of surveys. Prevalence was significantly higher in rural compared to urban areas.ConclusionTB burden continues to be high in India suggesting further strengthening of TB control activities.
Databáze: OpenAIRE
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