Process Chemistry in Antiviral Research
| Autor: | Mark McLaughlin, David M. Tschaen, Nobuyoshi Yasuda, Yong-Li Zhong, Hongming Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Elbasvir Sofosbuvir Process chemistry HIV Infections Hepacivirus Pharmacology 010402 general chemistry 01 natural sciences Antiviral Agents Drug Discovery Influenza Human medicine Animals Humans Intensive care medicine Darunavir HIV therapy Influenza treatment 010405 organic chemistry Chemistry virus diseases HIV General Chemistry Hepatitis C 0104 chemical sciences Grazoprevir Peramivir medicine.drug |
| Zdroj: | Topics in current chemistry (Cham). 374(6) |
| ISSN: | 2365-0869 |
| Popis: | This article reviews antiviral therapies that have been approved for human use during the last decade, with a focus on the process chemistry that enabled access to these important drugs. In particular, process chemistry highlights from the practical syntheses of the HCV drugs sofosbuvir (Gilead), grazoprevir (Merck), and elbasvir (Merck), the HIV therapy darunavir (Tibotec) and the influenza treatment peramivir (BioCryst) are presented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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