Cardiac and renal function in a large cohort of amateur marathon runners

Autor: Jürgen Lock, Henryk Dreger, Adrian C. Borges, Lars Brechtel, Harm Peters, Wasiem Sanad, Sabrina Schroeckh, Ingolf Schimke, Fabian Knebel, Sebastian Spethmann, Fabian Halleck, Sebastian Schattke, Gert Baumann, Bernd Hewing
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
medicine.medical_specialty
Diastolic function
Heart Ventricles
Physical fitness
education
Diastole
Renal function
Athletic Performance
Athlete’s heart
600 Technik
Medizin
angewandte Wissenschaften::610 Medizin und Gesundheit
Kidney
Kidney Function Tests
urologic and male genital diseases
Ventricular Function
Left
Running
Cohort Studies
Young Adult
Endurance training
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Natriuretic peptides
Aged
Angiology
biology
business.industry
Research
General Medicine
Middle Aged
Endurance exercise
medicine.anatomical_structure
Cystatin C
Radiology Nuclear Medicine and imaging
Echocardiography
Physical Fitness
Heart Function Tests
Physical Endurance
biology.protein
Cardiology and Cardiovascular Medicine
business
human activities
Cohort study
Zdroj: Cardiovascular Ultrasound
Popis: Background Participation of amateur runners in endurance races continues to increase. Previous studies of marathon runners have raised concerns about exercise-induced myocardial and renal dysfunction and damage. In our pooled analysis, we aimed to characterize changes of cardiac and renal function after marathon running in a large cohort of mostly elderly amateur marathon runners. Methods A total of 167 participants of the BERLIN-MARATHON (female n = 89, male n = 78; age = 50.3 ± 11.4 years) were included and cardiac and renal function was analyzed prior to, immediately after and 2 weeks following the race by echocardiography and blood tests (including cardiac troponin T, NT-proBNP and cystatin C). Results Among the runners, 58% exhibited a significant increase in cardiac biomarkers after completion of the marathon. Overall, the changes in echocardiographic parameters for systolic or diastolic left and right ventricular function did not indicate relevant myocardial dysfunction. Notably, 30% of all participants showed >25% decrease in cystatin C-estimated glomerular filtration rate (GFR) from baseline directly after the marathon; in 8%, we observed a decline of more than 50%. All cardiac and renal parameters returned to baseline ranges within 2 weeks after the marathon. Conclusions The increase in cardiac biomarkers after completing a marathon was not accompanied by relevant cardiac dysfunction as assessed by echocardiography. After the race, a high proportion of runners experienced a decrease in cystatin C-estimated GFR, which is suggestive of transient, exercise-related alteration of renal function. However, we did not observe persistent detrimental effects on renal function. Electronic supplementary material The online version of this article (doi:10.1186/s12947-015-0007-6) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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