Targeting receptor tyrosine kinase EphB4 in cancer therapy
| Autor: | Yinnan Chen, Yanmin Zhang, Hongmei Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Receptor EphB4 EPH receptor B2 Receptor tyrosine kinase Structure-Activity Relationship 03 medical and health sciences 0302 clinical medicine Neoplasms Biomarkers Tumor Animals Humans Ephrin Molecular Targeted Therapy Kinase activity Protein Kinase Inhibitors biology Erythropoietin-producing hepatocellular (Eph) receptor EPH receptor A2 Cell biology Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis ROR1 biology.protein Tyrosine kinase Signal Transduction |
| Zdroj: | Seminars in Cancer Biology. 56:37-46 |
| ISSN: | 1044-579X |
| Popis: | Eph receptors and their Eph receptor-interacting (ephrin) ligands together form an important cell communication system with diverse roles. Experimental evidence demonstrated Eph receptor bidirectional signaling with both tumor-suppressing and tumor-promoting activities in cancer cells. The tyrosine kinase EphB4, a member of the Eph receptor family, has been associated with tumor angiogenesis, growth and metastasis, thus making it a valuable and attractive target for drug design for therapeutic applications. In the past decade, many studies have focused on elucidating the structure and function of EphB4 in complex with its ligand ephrinB2 for their role in carcinogenesis. Meanwhile, an array of compounds targeting EphB4 have been studied and several selective inhibitors have been tested in clinical studies. This review discusses the structure and function of the EphB4 receptor, analyzes its potential as a target for anticancer therapy, and summarizes the information about inhibitors of EphB4 kinase activity. Conclusively, EphB4 is a challenging but promising therapeutic target in cancer. |
| Databáze: | OpenAIRE |
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