Cyclosporine Reduces Sclerosis in Morphea: A Retrospective Study in 12 Patients and a Literature Review
| Autor: | Nora Wutte, E. Aberer, Gabor Bali, Julia Frühauf |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Biopsy Dermatology Gastroenterology Scleroderma 030207 dermatology & venereal diseases 03 medical and health sciences Scleroderma Localized Young Adult 0302 clinical medicine Internal medicine medicine Humans Young adult Child Aged Retrospective Studies Skin 030203 arthritis & rheumatology Body surface area medicine.diagnostic_test business.industry Remission Induction Retrospective cohort study Middle Aged medicine.disease Surgery Tolerability Cyclosporine Elevated transaminases Female business Morphea Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | Dermatology (Basel, Switzerland). 232(4) |
| ISSN: | 1421-9832 |
| Popis: | Background: The treatment of severe morphea is challenging, and treatment experience concerning the use of immunosuppressive agents for this condition is limited. Objective: The purpose of this study is to analyze the use of cyclosporine, its tolerability, and its effect on skin sclerosis. Materials and Methods: Patients with severe morphea who underwent treatment with cyclosporine were studied retrospectively. Results: Five of 12 patients with morphea showed complete remission and 6 patients had partial remission at the end of therapy (9-46 months, median 14) under a median cyclosporine dose of 2.4 mg/kg. The mean affected body surface area fell from 50% (2-80, median 65) to 17% (0-40, median 18). Side effects were hypertension, elevated transaminases, cholesterol, and weight gain. Conclusion: Cyclosporine can be effective in morphea. The side effects were reversible. However, the duration of treatment with cyclosporine is limited because of its potential permanent side effects. Prospective placebo-controlled studies are needed to establish the superiority of cyclosporine over other immunosuppressive drugs in this setting. |
| Databáze: | OpenAIRE |
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