The European/international fibromuscular dysplasia registry and initiative (FEIRI) - Clinical phenotypes and their predictors based on a cohort of 1000 patients
| Autor: | Pappaccogli, M, Di Monaco, S, Warchoł-Celińska, E, Lorthioir, A, Amar, L, Aparicio, Ls, Beauloye, C, Bruno, Rm, Chenu, P, de Leeuw, P, De Backer, T, Delmotte, P, Dika, Z, Gordin, D, Heuten, H, Iwashima, Y, Krzesinski, Jm, Kroon, Aa, Mazzolai, L, Poch, E, Sarafidis, P, Seinturier, C, Spiering, W, Toubiana, L, Van der Niepen, P, van Twist, D, Visonà, A, Wautrecht, Jc, Witowicz, H, Xu, J, Prejbisz, A, Januszewicz, A, Azizi, M, Persu, A, European/International FMD Registry and Initiative (FEIRI), and the Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH) Collaborators: Lucas, S Aparicio, Alexandre, Persu, Marco, Pappaccogli, Christophe, Beauloye, Patrick, Chenu, Frank, Hammer, Pierre, Goffette, Parla, Astarci, André, Peeters, Robert, Verhelst, Miikka, Vikkula, Patricia Van der Niepen, Frank Van Tussenbroek, Tine De Backer, Sofie, Gevaert, Dimitri, Hemelsoet, Luc, Defreyne, Hilde, Heuten, Laetitia, Yperzeele, Thijs Van der Zijden, Jean-Philippe, Lengelé, Jean-Marie, Krzesinski, Muriel, Sprynger, Philippe, Delmotte, Peter, Verhamme, Thomas, Vanassche, Pasquale, Scoppettuolo, Jean-Claude, Wautrecht, Wouter, Vinck, Vassilev, Dobrin, Yaneva, Teodora, Jiguang, Wang, Jianzhong, Xu, Bojan, Jelaković, Zivka, Dika, Daniel, Gordin, Ilkka, Tikkanen, Maarit, Venermo, N Mäkelä, R, Pierre-François, Plouin, Xavier, Jeunemaitre, Laurent, Toubiana, Michel, Azizi, Laurence, Amar, Antoine, Chédid, Elie, Mousseaux, Aurélien, Lorthioir, Olivier, Ormezzano, Christopher, Seinturier, Frédéric, Thony, Felix, Mahfoud, Saarraaken, Kulenthiran, Pantelis, Sarafidis, Alexia, Piperidou, Michael, Doumas, George, S Stergiou, Demetrios, Vlahakos, Caitriona, Canning, Yehonatan, Sharabi, Alberto, Morganti, Rosa Maria Bruno, Stefano, Taddei, Caterina, Romanini, Ilaria, Petrucci, Franco, Rabbia, Silvia Di Monaco, Gian Paolo Rossi, Silvia, Lerco, Minuz, Pietro, Mansueto, Giancarlo, DE MARCHI, Sergio, Marcon, Denise, Patrizia, Salice, Adriana, Visonà, Paola, Bigolin, Viviana, Zingaretti, Rosario, Cianci, Marialuisa, Zedde, Maria Chiara Matteucci, Yoshio, Iwashima, Osami, Kawarada, Yoshito, Kadoya, Daan, J van Twist, Bram, Kroon, Peter de Leeuw, Wilko, Spiering, Bert-Jan van den Born, Aud, Høieggen, Martin Skage Sommer, Andrzej, Januszewicz, Ewa, Warchoł-Celińska, Aleksander, Prejbisz, Adam, Witkowski, Helena, Witowicz, Jacek, Kądziela, Aleksandra, Soplińska, Krzysztof, Pieluszczak, Katarzyna, Jóżwik-Plebanek, Magdalena, Januszewicz, Elżbieta, Florczak, Piotr, Dobrowolski, Eva, Szabóová, Marek, Hudák, Matej, Moščovič, Juan Diego Mediavilla, Fernando Jaen Aguila, Anna, Oliveras, Julian, Segura, Jose, C Prado, Nicolas Roberto Robles, Esteban, Poch, Enrique, Montagud-Marrahi, Alicia, Molina, Elena, Guillen, Marta, Burrel, Patricia Fernàndez De la Llama, Antonio, J Barros-Membrilla, Anders, Gottsäter, Gregor, Wuerzner, Lucia, Mazzolai, Giacomo, Buso, Faiçal, Jarraya, Hanen, Chaker, David, Adlam, Constantina, Chrysochou, Neeraj, Dhaun, Robert, W Hunter, Iain, Macintyre, David, Webb |
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| Přispěvatelé: | Public and occupational health, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, APH - Personalized Medicine, APH - Global Health, ACS - Heart failure & arrhythmias, Interne Geneeskunde, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology, CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/DDUV/GEHU - Génétique, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service de neurologie, UCL - (SLuc) Service de chirurgie cardiovasculaire et thoracique |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
renovascular hypertension Computed Tomography Angiography Physiology [SDV]Life Sciences [q-bio] Fibromuscular dysplasia 030204 cardiovascular system & hematology Magnetic resonance angiography 0302 clinical medicine Risk Factors Prevalence Registries Renovascular hypertension Stroke Computed tomography angiography medicine.diagnostic_test fibromuscular dysplasia dissection aneurysm stroke Incidence Dissection Age Factors Middle Aged Prognosis 3. Good health Europe Phenotype Cohort cardiovascular system Female Cardiology and Cardiovascular Medicine circulatory and respiratory physiology Adult medicine.medical_specialty Asia Tunisia Aneurysm Argentina Risk Assessment 03 medical and health sciences Sex Factors stomatognathic system Predictive Value of Tests Physiology (medical) Internal medicine medicine Humans cardiovascular diseases Aged business.industry medicine.disease Aortic Dissection Stenosis Angiography business Magnetic Resonance Angiography 030217 neurology & neurosurgery |
| Zdroj: | Cardiovascular research, 117(3), 950-959. Oxford University Press Cardiovascular Research, 117(3), 950-959. Oxford University Press Cardiovascular Research Cardiovascular Research, Oxford University Press (OUP), 2021, 117 (3), pp.950-959. ⟨10.1093/cvr/cvaa102⟩ Cardiovascular research, Vol. 117, no. 3, p. 950-959 (2021) |
| ISSN: | 0008-6363 |
| DOI: | 10.1093/cvr/cvaa102⟩ |
| Popis: | AIMS: Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections. METHODS AND RESULTS: All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on CTA, MRA and/or catheter-based angiography were eligible.Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46±16 years (12% ≥65yo), 86% were hypertensive, 72% had multifocal and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients ≥65yo had more often multifocal FMD, lower eGFR and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke and multivessel FMD. CONCLUSIONS: The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management and follow-up of FMD. TRANSLATIONAL PERSPECTIVE: Fibromuscular dysplasia (FMD) is nowadays considered as a systemic arterial disease, warranting brain-to-pelvis vascular imaging in all patients. However, most current evidence is derived from a limited number of expert centres. Furthermore, one size may not fit all. Based on analysis of the first thousand patients enrolled in the European/International FMD registry (46 centres; 22 countries) we characterized distinct patient profiles according to FMD subtype, age and gender and identified predictors of widespread disease, aneurysms and dissections, paving the way for individualized management and follow-up. Further studies will allow refining patient characterization according to ethnicity, genetic profile and imaging biomarkers. |
| Databáze: | OpenAIRE |
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