Revascularization with percutaneous coronary intervention does not affect androgen status in males with chronic stable angina pectoris

Autor: J. N. Gosai, Kevin S. Channer, Theodora Nikolaidou, T. H. Jones, Paul Morris, P. Charalampidis, Ever D Grech, Yasir Parviz
Rok vydání: 2015
Předmět:
Male
medicine.medical_specialty
medicine.drug_class
Urology
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Revascularization
Angina
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Endocrinology
Sex hormone-binding globulin
Percutaneous Coronary Intervention
Risk Factors
Internal medicine
Sex Hormone-Binding Globulin
medicine
Humans
Testosterone
cardiovascular diseases
Angina
Stable
Prospective Studies
Aged
biology
business.industry
Depression
Percutaneous coronary intervention
Testosterone (patch)
Middle Aged
Androgen
medicine.disease
Coronary arteries
medicine.anatomical_structure
Treatment Outcome
Reproductive Medicine
Cardiology
biology.protein
business
Stress
Psychological
Zdroj: Andrology. 4(3)
ISSN: 2047-2927
Popis: There is a clear association between low serum testosterone and coronary artery disease (CAD) in men. Hypotestosteronaemia is associated with accelerated atherosclerosis and a quarter of men with CAD are biochemically hypogonadal. Amongst those with CAD, hypotestosteronaemia is associated with increased mortality. Testosterone vasodilates coronary arteries, and exogenous testosterone reduces ischaemia. Whether hypotestosteronaemia is a cause or a consequence of CAD remains unanswered. The aim of this prospective observational study was to investigate whether coronary revascularization affected androgen status in men with stable angina pectoris. Twenty five men (mean age 62.7, SD 9.18) with angiographically significant CAD and symptomatic angina underwent full coronary revascularization by percutaneous coronary intervention. Androgen status and symptoms of angina, stress, depression and sexual function were assessed before, and at one and 6 months after the coronary revascularization. All patients underwent complete revascularization which was associated with a significant reduction in angina symptoms and ischaemia. No significant difference was seen in total testosterone (11.33 nmol/L baseline; 12.56, 1 month post; 13.04 at 6 months; p = 0.08). A significant and sustained rise in sex hormone-binding globulin was seen (33.99 nm/L baseline; 36.11 nm/L 1 month post PCI; 37.94 nm/L at 6 months; p = 0.03) Overall, there was no significant alteration in any other marker of androgen status including free testosterone or bioavailable testosterone. There was no change in symptoms of anxiety, depression or sexual function. Coronary revascularization has no sustained effect on androgen status. This supports the hypothesis that hypotestosteronaemia is not a consequence of angina pectoris or myocardial ischaemia.
Databáze: OpenAIRE
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