Ameliorative effect of chromium-d-phenylalanine complex on indomethacin-induced inflammatory bowel disease in rats
| Autor: | B.S. Thippeswamy, Veeresh P. Veerapur, Shivsharan B. Dhadde, S. Nagarjun, Baburao N. Chandakavathe |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.drug_class Phenylalanine medicine.medical_treatment Indomethacin Ileum Pharmacology Inflammatory bowel disease Anti-inflammatory Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chromium Compounds Lactate dehydrogenase medicine Animals Rats Wistar Peroxidase biology Anti-Inflammatory Agents Non-Steroidal General Medicine Glutathione Inflammatory Bowel Diseases medicine.disease Rats Sulfasalazine 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Myeloperoxidase Immunology biology.protein Lipid Peroxidation |
| Zdroj: | Biomedicine & Pharmacotherapy. 89:1061-1066 |
| ISSN: | 0753-3322 |
| Popis: | Present study was designed to evaluate the effect of chromium-d-phenylalanine complex (Cr (d-phe)3) on indomethacin-induced inflammatory bowel disease (IBD) in rats. Adult Wistar rats were pretreated with vehicle/Cr (d-phe)3 (30, 60 and 90μg/kg, p.o.) for 11days. On day 8 and 9, after one h of the above mentioned treatment, indomethacin (7.5mg/kg/day,s.c.) was administered to induce IBD. On day 12, blood samples were collected from animals for lactate dehydrogenase (LDH) estimation and ileum was isolated for macroscopic scoring, biochemical estimation (lipid peroxidation, reduced glutathione and myeloperoxidase activity) and histopathological study. Administration of indomethacin significantly altered the serum LDH, macroscopic and microscopic appearance and biochemical parameters in ileum tissue. Cr (d-phe)3, at all the tested doses, caused a significant reversal of changes induced by indomethacin. Present study demonstrates the protective effect of Cr (d-phe)3 against indomethacin-induced IBD in rats. The observed protective effect might be attributed to the antioxidant and anti-inflammatory properties of Cr (d-phe)3. |
| Databáze: | OpenAIRE |
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