Calcium-activated non-selective channels in the nervous system
| Autor: | T. H. Mueller, L. D. Partridge, Dieter Swandulla |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Nervous system
General Neuroscience T-type calcium channel food and beverages chemistry.chemical_element Depolarization Biology Calcium medicine.disease Nervous System medicine.anatomical_structure chemistry Cytoplasm Neuroblastoma medicine Myocyte Animals Humans Nervous System Physiological Phenomena Neurology (clinical) Calcium Channels Neuroscience Function (biology) |
| Zdroj: | Brain research. Brain research reviews. 19(3) |
| Popis: | In the decade, since the first description of calcium-activated non-selective (CAN) channels in cardiac myocytes, pancreatic acini and neuroblastoma, this type of channel has been shown to have a ubiquitous distribution across a variety of tissues. Recently, their role in the function of cells of the nervous system has become better delineated. Because CAN channels pass depolarizing current, respond to cytoplasmic Ca2+ activity and do not inactivate, they are capable of producing maintained depolarization of neurons. This property endows upon CAN channels an important role in both physiological functions and pathological processes of the nervous system. |
| Databáze: | OpenAIRE |
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