Elevated natural killer cytotoxicity in HLA-B8 and HLA-DR3-positive individuals
| Autor: | Marek Jakóbisiak, J Schlaut, Susan L. Saidman, John B. Dossetor, Feldgerita Pazderka |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Linkage disequilibrium Genetic Linkage Genes MHC Class II Immunology HLA-DR3 Biology HLA-B8 Antigen HLA-DR3 Antigen Antigen HLA Antigens Humans Immunology and Allergy In patient Cytotoxicity Immunologic Surveillance Immunological Surveillance Gene Immunity Cellular Histocompatibility Antigens Class II Middle Aged Natural killer T cell Killer Cells Natural Female |
| Zdroj: | Immunology Letters. 12:61-63 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/0165-2478(86)90083-0 |
| Popis: | Increased natural killer cytotoxicity in persons positive for HLA-B8 and HLA-DR3 has been found. It is suggested that linkage disequilibrium between the genes coding for HLA-B8 and HLA-DR3 may have evolved as a result of strengthened immunological surveillance in individuals bearing them, as decrease in the frequency of both these antigens has recently been reported in patients with tumours. |
| Databáze: | OpenAIRE |
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