THE PATTERN OF DESMIN FILAMENTS IN MYOCARDIAL DISARRAY
| Autor: | Pietro Gallo, Malcolm D. Silver, Paola Francalanci, Paola Bernucci, Giulia d'Amati |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Biopsy Cardiomyopathy macromolecular substances Biology Left ventricular hypertrophy Desmin Pathology and Forensic Medicine Muscle hypertrophy medicine Humans Myocyte cardiovascular diseases Intermediate filament Aged Myocardium Hypertrophic cardiomyopathy Anatomy Cardiomyopathy Hypertrophic Middle Aged medicine.disease Immunohistochemistry desmin hypertrophic cardiomyopathy immunohistochemistry intermediate filaments myofiber disarray Myocardial disarray Tetralogy of Fallot cardiovascular system Female Hypertrophy Left Ventricular |
| Popis: | "Myofiber disarray" defines a nonparallel arrangement of cardiac myocytes. The presence of a sufficient quantity of myocardial fibers showing this change is considered to be a specific histological feature of hypertrophic cardiomyopathy (HCM). However, small zones of myofiber disarray are found in both cardiac hypertrophy and other pathological conditions. Recently, we demonstrated an altered pattern of desmin intermediate filaments in disarrayed myofibers from specimens of HCM. To test the hypothesis that desmin alterations might be specific for cardiomyopathy, we performed an immunohistochemical study on myocardial surgical samples from 11 patients with HCM and from 12 patients with tetralogy of Fallot (toF) on 14 endomyocardial biopsy specimens (EMBs) from transplant recipients with myofiber disarray surrounding areas of scarring (previous biopsy site) and on specimens of four autoptic hearts with severe acquired left ventricular hypertrophy. Disarrayed myofibers from all specimens of HCM showed the following abnormalities in the pattern of desmin intermediate filament distribution: (1) decrease or loss of labeling of intercalated discs and Z bands, (2) longitudinal arrangement of desmin intermediate filaments, and (3) intense, granular staining of several myocytes. This spectrum of desmin alterations was never observed in disarrayed myofibers in specimens of toF or acquired myocardial hypertrophy or in EMBs. Altered distribution of desmin intermediate filaments seems to be specific to myofiber disarray in HCM and it may play a role in the altered myocyte arrangement in HCM. |
| Databáze: | OpenAIRE |
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