Continuous, simultaneous cocrystallization and formulation of Theophylline and 4-Aminobenzoic acid pharmaceutical cocrystals using twin screw melt granulation
| Autor: | Rahamatullah Shaikh, Denise M. Croker, Gavin Walker |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Cocrystal Dosage form Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound Tableting Granulation 0302 clinical medicine Theophylline 4-Aminobenzoic acid medicine Technology Pharmaceutical Temperature 021001 nanoscience & nanotechnology chemistry Chemical engineering 0210 nano-technology Crystallization 4-Aminobenzoic Acid medicine.drug Tablets |
| Zdroj: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 137 |
| ISSN: | 1879-0720 |
| Popis: | In this work a cocrystal of Theophylline and 4Aminobenzoic acid was successfully produced and formulated using a hydrophilic binder with a novel continuous melt granulation approach. This melt granulation was followed with direct compression to generate oral solid dosage forms. The study revealed that the processing temperature, molecular weight of the binder and binder concentration were the most effective parameters for the production and formulation of high purity cocrystals. Superior tableting performance was observed for melt granulated cocrystals as compared with extruded cocrystals and pure theophylline. Moreover the prepared THP-4ABA melt granulated cocrystals were stable for 14 days (50 °C and 75% RH). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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