Brain activity during transient sadness and happiness in healthy women
| Autor: | Priti I. Parekh, Barry Horwitz, Terence A. Ketter, Robert M. Post, Peter Herscovitch, Mark S. George |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Brain activity and meditation media_common.quotation_subject Emotions Happiness behavioral disciplines and activities Functional Laterality Limbic system Oxygen Radioisotopes Task Performance and Analysis mental disorders Limbic System medicine Humans media_common Cerebral Cortex Temporal cortex Depressive Disorder Depression Putamen Brain Sadness Affect Psychiatry and Mental health medicine.anatomical_structure Cerebral blood flow Cerebral cortex Cerebrovascular Circulation Female Psychology Neuroscience psychological phenomena and processes Tomography Emission-Computed |
| Zdroj: | American Journal of Psychiatry. 152:341-351 |
| ISSN: | 1535-7228 0002-953X |
| Popis: | Objective: The specifit brain regions involved in the normal emotional states of transient sadness or happiness are poorly understood. The authors therefore sought to determine if H 2 15 O position emission tomography (PET) might demonstrate changes in regional cerebral blood flow (rCBF) associated with transient sadness or happiness in healthy adult women. Method: Eleven healthy and never mentally ill adult women were scanned, by using PET and H 2 15 O, during happy, sad, and neutral states induced by recalling affect-appropriate life events and looking at happy, sad, or neutral human fates. Results: Compared to the neutral condition, transient sadness significantly activated bilateral limbic and paralimbic structures (cingulate, medial prefrontal, and mesial temporal cortex), as well as brainstem, thalamus, and caudate/putamen. In contrast, transient happiness had no areas of signifitantly increased activity but was associated with significant and widespread reductions in cortical rCBF, especially in the right prefrontal and bilateral temporal-parietal regions. Conclusions: Transient sadness and happiness in healthy volunteer women are accompanied by significant changes in regional brain activity in the limbic system, as well as other brain regions. Transient sadness and happiness affect different brain regions in divergent directions and are not merely opposite activity in identical brain regions. These findings have implications for understanding the neural substrates of both normal and pathological emotion |
| Databáze: | OpenAIRE |
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