Serum and ascites chromogranin-A in patients with metastatic neuroendocrine tumors
| Autor: | Thomas Curran, Thomas D. Schiano, Viktoriya Khaitova, Richard R.P. Warner, Michelle K. Kim, Michail K. Shafir |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Carcinoid Tumor Neuroendocrine tumors Gastroenterology Sensitivity and Specificity Endocrinology Internal medicine Ascites Internal Medicine Medicine Humans In patient Neoplasm Metastasis Survival analysis Aged Hepatology biology business.industry Chromogranin A Middle Aged medicine.disease Survival Analysis Neuroendocrine Tumors Lymphatic system Heart failure biology.protein Portal hypertension Female medicine.symptom business |
| Zdroj: | Pancreas. 40(4) |
| ISSN: | 1536-4828 |
| Popis: | Objectives Ascites secondary to neuroendocrine tumor metastases may arise from a variety of mechanisms. Our aim was to measure serum and ascitic chromogranin-A (CgA) to help determine whether ascites resulted from intraperitoneal/retroperitoneal disease burden or from other carcinoid complications such as congestive heart failure or portal hypertension. Methods Patients with metastatic neuroendocrine tumors and ascites were identified. Chromogranin-A was obtained and measured from both serum and ascites. The causes of carcinoid ascites was categorized into 2 groups: high intraperitoneal or retroperitoneal disease burden (ie, peritoneal metastases and/or lymphatic obstruction; n = 12, group 1) or other organ-specific carcinoid complications such as CHF or portal hypertension (n = 12, group 2). Results An ascites CgA/serum CgA ratio greater than 1 was more likely to be found in group 1 (P = 0.01). This ratio produced 100% sensitivity and 75% specificity for ascites secondary to peritoneal metastases and/or lymphatic obstruction. Conclusions An ascites CgA/serum CgA ratio greater than 1 produces excellent accuracy in predicting peritoneal metastases and/or retroperitoneal disease as the cause of ascites in the setting of metastatic carcinoid. This test may play a role in the earlier identification of those patients who may be well served by aggressive management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|