Hyperglycemic Activity of Some Non-Nitrosated Streptozotocin Analogs
| Autor: | G. F. Tutwiler, N. D. Heindel, H. D. Burns, T. J. Kirsch, G. J. Bridi |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Streptozocin General Biochemistry Genetics and Molecular Biology Structure-Activity Relationship chemistry.chemical_compound Internal medicine Diabetes mellitus Diabetes Mellitus medicine Animals Structure–activity relationship Sugar moiety Early onset Glucose tolerance test medicine.diagnostic_test Chemistry nutritional and metabolic diseases Nitroso Glucose Tolerance Test Streptozotocin medicine.disease Rats Endocrinology Hyperglycemia medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 152:195-198 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-152-39359 |
| Popis: | Six non-nitrosated and three nitrosated analogs of the antitumor and diabetogenic agent, streptozotocin, have been found to produce hyperglycemia in fasted rats. The hyperglycemia produced by the non-nitrostaed analogs was of early onset and did not result in the production of permanent diabetes. The data emphasizes the important role of the nitroso group of streptozotocin in the production of the hypoglycemic and permanent diabetic phases while the sugar moiety may have a direct influence on production of the early hyperglycemia phase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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