Antimicrobial activity of a novel adhesive containing chlorhexidine gluconate (CHG) against the resident microflora in human volunteers
| Autor: | Neal Carty, Anne Marie Wibaux, Colleen Ward, Daryl S. Paulson, Peter C. Johnson |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
antisepsis dressing cutaneous flora Human skin IV securement Microbiology Adhesives Antimicrobial effect Chlorhexidine gluconate Humans Medicine Pharmacology (medical) Original Research Skin catheter-related infections Pharmacology Infection Control business.industry Microbiota Chlorhexidine Significant difference vascular access Antimicrobial Bandages Bacterial Load Healthy Volunteers Anti-Bacterial Agents Infectious Diseases Adhesive business Bandage medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dku096 |
| Popis: | Objectives To evaluate the antimicrobial activity of a new, transparent composite film dressing, whose adhesive contains chlorhexidine gluconate (CHG), against the native microflora present on human skin. Methods CHG-containing adhesive film dressings and non-antimicrobial control film dressings were applied to the skin on the backs of healthy human volunteers without antiseptic preparation. Dressings were removed 1, 4 or 7 days after application. The bacterial populations underneath were measured by quantitative cultures (cylinder-scrub technique) and compared with one another as a function of time. Results The mean baseline microflora recovery was 3.24 log10 cfu/cm(2). The mean log reductions from baseline measured from underneath the CHG-containing dressings were 0.87, 0.78 and 1.30 log10 cfu/cm(2) on days 1, 4 and 7, respectively, compared with log reductions of 0.67, -0.87 and -1.29 log10 cfu/cm(2) from underneath the control film dressings. There was no significant difference between the log reductions of the two treatments on day 1, but on days 4 and 7 the log reduction associated with the CHG adhesive was significantly higher than that associated with the control adhesive. Conclusions The adhesive containing CHG was associated with a sustained antimicrobial effect that was not present in the control. Incorporating the antimicrobial into the adhesive layer confers upon it bactericidal properties in marked contrast to the non-antimicrobial adhesive, which contributed to bacterial proliferation when the wear time was ≥4 days. |
| Databáze: | OpenAIRE |
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