The Role of Radiotherapy in the Treatment of Primary or Recurrent Desmoid Tumors and Long-Term Results
| Autor: | Didem Çolpan Öksüz, Murat Hiz, Elif Eda Tiken, Nil Molinas Mandel, Şefika Arzu Ergen, Sergülen Dervişoğlu, Sedat Koca, Fazilet Oner Dincbas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Side effect medicine.medical_treatment desmoid tumor Aggressive fibromatosis lcsh:Medicine 03 medical and health sciences 0302 clinical medicine Aggressive fibromatosis desmoid tumor local control radiotherapy Biopsy medicine radiotherapy Univariate analysis medicine.diagnostic_test business.industry Wide local excision lcsh:R General Medicine medicine.disease Surgery Radiation therapy 030104 developmental biology local control 030220 oncology & carcinogenesis Resection margin Original Article Sarcoma business |
| Zdroj: | Balkan Medical Journal, Vol 33, Iss 3, Pp 316-321 (2016) Volume: 33, Issue: 3 316-321 Balkan Medical Journal |
| ISSN: | 2146-3131 2146-3123 |
| Popis: | Background: Desmoid tumors are uncommon and benign mesenchymal neoplasms. The optimal treatment of patients with desmoid tumors is still controversial. Surgery is the primary treatment for locally invasive or recurrent desmoid tumors. Also, radiotherapy is a treatment option for patients at high risk for local failure such as those with positive margins or recurrent and unresectable tumors. Aims: To report our institutional experience and long-term results of patients with desmoid tumors who received radiotherapy. Study Design: Retrospective cross-sectional study. Methods: Between 1980 and 2009, 20 patients who received radiotherapy (RT) in our institution were analyzed. The majority of patients (80%) were referred with a recurrent tumor after previous surgery. Thirteen patients underwent marginal resection, 4 had wide local excision and 3 patients had only biopsy. Resection margin was positive in 15 (75%) patients. All patients received radiation therapy. The median prescribed dose was 60 Gy. Five patients received less than 54 Gy. Results: The median follow-up time was 77.5 months (28-283 months). Nine patients developed local recurrence after RT. Seven local failures (78%) were in field. Time to local recurrence ranged from 3-165 months (median 33 months). The 2-5 year local control (LC) rates were 80% and 69%, respectively. On univariate analysis, the 5 year local control rate was significantly better in the patients treated with ≥54 Gy than in patients who received |
| Databáze: | OpenAIRE |
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