Formulation development and evaluation of lidocaine hydrochloride loaded in chitosan-pectin-hyaluronic acid polyelectrolyte complex for dry socket treatment
| Autor: | Sucharat Limsitthichaikoon, Nuttawut Supachawaroj, Teerasak Damrongrungruang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
food.ingredient
Pectin Hyaluronic acid Pharmaceutical Science Zn zinc sulphate Lidocaine Hydrochloride RM1-950 Chitosan chemistry.chemical_compound food PEC Chitosan-Pectin- Hyaluronic acid Polyelectrolyte Complex Zeta potential Mucoadhesion 32 factorial design HA hyaluronic acid Pharmacology LH lidocaine hydrochloride Chromatography Factorial experiment Polyelectrolyte Dry socket treatment Lidocaine hydrochloride LC lidocaine hydrochloride loaded in chitosan-pectin-hyaluronic acid polyelectrolyte complex chemistry Polyelectrolyte complex Original Article Particle size Therapeutics. Pharmacology PDI polydispersion index |
| Zdroj: | Saudi Pharmaceutical Journal : SPJ Saudi Pharmaceutical Journal, Vol 29, Iss 9, Pp 1070-1081 (2021) |
| ISSN: | 1319-0164 |
| Popis: | The main purpose of this study was to assess a lidocaine hydrochloride-loaded chitosan-pectin-hyaluronic polyelectrolyte complex for rapid onset and sustained release in dry socket wound treatment. Nine formulations (LCs) of lidocaine hydrochloride (LH) loaded into a chitosan–pectin–hyaluronic polyelectrolyte complex (PEC) were assessed using full factorial design (two factors × three levels). The formulations ranged between 4 and 10% w/w LH and 0.5–1.5% w/w HA. The following physicochemical properties of LCs were characterized: size, zeta potential, % entrapment efficiency, viscosity, mucoadhesiveness, % drug release, morphology, storage stability, and cytotoxicity. The particle size, zeta potential, % EE, viscosity, and % mucoadhesion increased with increasing LH and HA concentrations. Rapid release of LH followed a zero-order model, and a steady-state percentage of the drug was released over 4 h. LCs were found to be non-cytotoxic compared to LH solution. LH loaded into PEC demonstrated appropriate characteristics—including suitable rate of release—and fit a zero-order model. Furthermore, it was not cytotoxic and showed good stability in a high-HA formula, making it a promising candidate for future topical oral formulations. |
| Databáze: | OpenAIRE |
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