Association of circulating miR-20a, miR-27a, and miR-126 with non-alcoholic fatty liver disease in general population
Autor: | Shuji Hashimoto, Koji Ohashi, Naohiro Ichino, Hiroaki Ishikawa, Koji Suzuki, Ryosuke Fujii, Keisuke Osakabe, Keiko Sugimoto, Yoshiji Ohta, Mirai Yamazaki, Eiji Munetsuna, Yoshitaka Ando, Ryoji Teradaira, Hiroya Yamada, Nobuyuki Hamajima, Genki Mizuno |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Epidemiology Population lcsh:Medicine Disease Real-Time Polymerase Chain Reaction Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Japan Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Circulating MicroRNA education lcsh:Science Aged education.field_of_study Multidisciplinary business.industry Fatty liver lcsh:R nutritional and metabolic diseases Odds ratio Middle Aged medicine.disease Obesity digestive system diseases MicroRNAs Cross-Sectional Studies 030104 developmental biology 030220 oncology & carcinogenesis Female lcsh:Q Metabolic syndrome business Biomarkers |
Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity, metabolic syndrome, and type II diabetes mellitus. Recently, circulating microRNAs (miRNAs) have been proposed as useful disease biomarkers. We examined whether circulating miRNAs, such as miR-20a, miR-27a, and miR-126, were useful biomarkers for NAFLD. We conducted a cross-sectional analysis of 527 subjects aged 39 years or older who had undergone a health examination in the Yakumo Study. Of the residents, 92 were diagnosed with NAFLD using a registered medical sonographer. Serum miR-20a, miR-27a and miR-126 levels were measured by quantitative real-time PCR. We then calculated the odds ratios for serum miRNA level changes according to the severity of NAFLD using normal liver status as the reference group. Serum levels of miR-20a and 27a, but not miR-126, were significantly lower in NAFLD subjects than normal subjects. Serum miR-20a and miR-27a levels were significantly lower in both male and female severe NAFLD subjects. Logistic regression analysis showed a significant relationship between low circulating miR-20a and 27a levels and severe NAFLD. Down-regulated circulating miR-20a and 27a levels were significantly associated with severe NAFLD in the general population. Circulating miR-20a and miR-27a may be useful biomarkers for severe NAFLD. |
Databáze: | OpenAIRE |
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