A General Palladium-Catalyzed Amination of Aryl Halides with Ammonia

Autor:	Matthias Beller, Thomas Schulz, Andreas Dumrath, Helfried Neumann, Stephan Enthaler, Benjamin Schäffner, Anke Spannenberg, Armin Börner, Christian Torborg
Rok vydání:	2009
Předmět:	Ligand Aryl Organic Chemistry chemistry.chemical_element Homogeneous catalysis General Chemistry Medicinal chemistry Catalysis chemistry.chemical_compound Ammonia chemistry Organic chemistry Phosphine Amination Palladium
Zdroj:	Chemistry - A European Journal. 15:4528-4533
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.200802678
Popis:	A new robust palladium/phosphine catalyst system for the selective monoarylation of ammonia with different aryl bromides and chlorides has been developed. The active catalyst is formed in situ from [Pd(OAc)(2)] and air- and moisture-stable phosphines as easy-to-handle pre-catalysts. The productivity of the catalyst system is comparable to that of competitive Pd/phosphine systems; full conversion is achieved with most substrates with 1-2 mol % of Pd source and a fourfold excess of ligand (L).
Databáze:	OpenAIRE
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