Antilipolytic effect of p-myristyloxy-alpha-methylcinnamic acid (LK-903 acid) as a mechanism of the hypolipidemic action of its alpha-monoglyceride (LK-903)

Autor:	Takeyama Shigeyuki, Takashima Kohki
Rok vydání:	1978
Předmět:	Male Time Factors Glyceride Adipose tissue Biochemistry Cinnamic acid Glycerides chemistry.chemical_compound Glycerol Lipolysis Animals Drug Interactions Hypolipidemic Agents Pharmacology Cholesterol Monoglyceride Lipid Metabolism Lipids Diet Rats chemistry Adipose Tissue Cinnamates
Zdroj:	Biochemical pharmacology. 27(22)
ISSN:	0006-2952
Popis:	In a study of the mechanism of hypolipidemic action of α -mono- p -myristyloxy-α'-methyl-cinnamoyl glycerol (LK-903), the hydrolyed cinnamic acid moiety (LK-903 acid) was found to inhibit in vitro the lipolysis manifested by rat epididymal adipocytes. Its antilipolytic action appears to be the result of inhibition of cyclic AMP formation in the fat cells in analogy with the mechanism of feedback inhibition of lipolysis by free fatty acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecea6e1a93f382e60f2d5c5355a67237 https://pubmed.ncbi.nlm.nih.gov/728215 Zobrazit plný text záznamu