Mac-2-Binding Protein Glycosylation Isomer as a Novel Predictor of Hepatocellular Carcinoma Recurrence in Patients with Hepatitis C Virus Eradication
Autor: | Makoto Edagawa, Kenkichi Hashimoto, Shohei Yamaguchi, Akihiro Sakai, Shigeyuki Nagata, Takuro Kometani, Kyohei Yugawa, Takashi Maeda, Kozo Konishi, Takahiro Omine |
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Rok vydání: | 2021 |
Předmět: |
Liver Cirrhosis
medicine.medical_specialty Glycosylation Carcinoma Hepatocellular Hepatitis C virus Hepacivirus medicine.disease_cause Gastroenterology Antiviral Agents chemistry.chemical_compound Surgical oncology Internal medicine Medicine Humans In patient Retrospective Studies business.industry Liver Neoplasms virus diseases Retrospective cohort study medicine.disease Hepatitis C digestive system diseases Oncology chemistry Hepatocellular carcinoma Biomarker (medicine) Surgery business Mac 2 binding protein |
Zdroj: | Annals of surgical oncology. 29(4) |
ISSN: | 1534-4681 |
Popis: | Hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) can recur even after achievement of a sustained virologic response (SVR). Mac-2-binding protein glycosylation isomer (M2BPGi) is a newly identified biomarker correlated with liver fibrosis. This study aimed to clarify outcomes for patients with an SVR and to assess the prognostic value of M2BPGi.This single-center retrospective study analyzed patients who underwent surgical resection for primary HCV-related HCC between 2008 and 2018. The study enrolled 81 patients whose M2BPGi could be evaluated after an SVR. The relationship between liver fibrosis-related factors and scores (including M2BPGi) and HCC recurrence, was evaluated.Of the 81 patients, 57 (70.4%) with HCV-related HCC obtained an SVR, whereas 24 patients (29.6%) did not. The patients with an SVR had a significantly more favorable recurrence-free survival (RFS) than the patients with no SVR (P0.0001, log-rank). Among the SVR groups, M2BPGi predicted a shorter RFS after hepatic resection with a higher degree of accuracy than other markers and scores in the SVR group. The high-M2BPGi group had worse liver function, RFS, and overall survival (OS) (P = 0.0014 and 0.0006, log-rank, respectively). In the multivariate analysis, high M2BPGi was significantly associated with worse RFS and OS.Even after achievement of an SVR, the risk of HCC recurrence cannot be eliminated. Measurement of M2BPGi after an SVR can be applied for risk stratification in the assessment of patients with HCV-related HCC. |
Databáze: | OpenAIRE |
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