Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
| Autor: | Theo K. Bammler, Matt Kaeberlein, Benjamin Barré, Vadim N. Gladyshev, Xuming Zhou, Benjamin R Harrison, Cheryl Zi Jin Phua, Weiqiang Liu, Siming Ma, Daniel E. L. Promislow, Xiaqing Zhao, Lu Wang, Mitchell B. Lee, Brian M. Wasko, Alexander Tyshkovskiy, Alaattin Kaya |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
media_common.quotation_subject Science Genes Fungal S. cerevisiae Genomics Saccharomyces cerevisiae Biology yeast General Biochemistry Genetics and Molecular Biology Transcriptome Saccharomyces longevity Gene Regulatory Networks S. paradoxus Gene–environment interaction Biology (General) Gene media_common General Immunology and Microbiology Phylogenetic tree General Neuroscience aging Longevity Genetics and Genomics General Medicine multi-omics Phenotype gene-environment interaction Evolutionary biology Medicine natural lifespan variation Function (biology) Research Article |
| Zdroj: | eLife, Vol 10 (2021) eLife |
| Popis: | To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species, within a controlled environment. In particular, this approach may lead to understanding mechanisms underlying natural variation in lifespan. Here, we analyzed 76 ecologically diverse wild yeast isolates and discovered a wide diversity of replicative lifespan (RLS). Phylogenetic analyses pointed to genes and environmental factors that strongly interact to modulate the observed aging patterns. We then identified genetic networks causally associated with natural variation in RLS across wild yeast isolates, as well as genes, metabolites, and pathways, many of which have never been associated with yeast lifespan in laboratory settings. In addition, a combined analysis of lifespan-associated metabolic and transcriptomic changes revealed unique adaptations to interconnected amino acid biosynthesis, glutamate metabolism, and mitochondrial function in long-lived strains. Overall, our multiomic and lifespan analyses across diverse isolates of the same species shows how gene–environment interactions shape cellular processes involved in phenotypic variation such as lifespan. |
| Databáze: | OpenAIRE |
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