Experimental Encephalomyocarditis Virus Infection in Pigs
| Autor: | Paolo Stefano Marcato, Marcella Spinaci, L. Sidoli, Giuseppe Sarli, E Foni, G. Barigazzi, L. Della Salda |
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| Rok vydání: | 1993 |
| Předmět: |
Swine Diseases
Emc virus biology Swine Inoculation Rectum Spleen General Medicine biology.organism_classification Virology Virus Nasal Mucosa Cardiovirus medicine.anatomical_structure Nasal Swab Cardiovirus Infections Leukocytes medicine biology.protein Animals Viral disease Encephalomyocarditis virus Antibody |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1439-0450 0931-1793 |
| DOI: | 10.1111/j.1439-0450.1993.tb00149.x |
| Popis: | Summary A field isolate of Encephalomyocarditis (EMC) virus was inoculated intravenously into 8 pigs. Four animals died at post inoculation day (PID) 2, the remaining being sacrificed at PID 5, 7, 11 and 15. Two control, in-contact pigs were sacrificed at PID 19. Virus was isolated from leucocytes and nasal swabs until PID 4, from rectal swabs until PID 2 and, in the pigs found dead at PID 2, from several organs. EMC virus was further isolated from brain and spleen of the pig sacrificed at PID 7. One of the 2 control pigs became infected: virus was isolated from nasal swabs at days 6 and 7 and from leucocytes at day 4 of the experiment. Serumneutralizing (SN) antibody was detected in the injected pigs starting from PID 4; two days later, it was also revealed in the infected, in-contact control. To our knowledge, this is the first report of an experimental transmission of EMC virus infection in pigs by contact exposure. |
| Databáze: | OpenAIRE |
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