Reduced ocular dominance plasticity and long-term potentiation in the developing visual cortex of protein kinase A RIIalpha mutant mice
| Autor: | Nigel W. Daw, Yan Rao, Adrienne LaRue, Yupeng Yang, Quentin S. Fischer, G. Stanley McKnight |
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| Rok vydání: | 2004 |
| Předmět: |
Genotype
genetic structures Long-Term Potentiation Action Potentials In Vitro Techniques Biology Polymerase Chain Reaction Ocular dominance Mice Reference Values Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit Neuroplasticity medicine Animals RNA Messenger Protein kinase A Visual Cortex Mice Knockout Neurons Neuronal Plasticity General Neuroscience Dose-Response Relationship Radiation Long-term potentiation Cyclic AMP-Dependent Protein Kinases Electric Stimulation eye diseases Dominance Ocular Electrophysiology Mice Inbred C57BL Monocular deprivation Visual cortex medicine.anatomical_structure Animals Newborn Mutation Synaptic plasticity Knockout mouse Sensory Deprivation Neuroscience |
| Zdroj: | European Journal of Neuroscience. 20:837-842 |
| ISSN: | 1460-9568 0953-816X |
| DOI: | 10.1111/j.1460-9568.2004.03499.x |
| Popis: | The cAMP-dependent protein kinase (PKA) signalling pathway has been shown to play an important role in long-term potentiation (LTP) and depression (LTD), and ocular dominance plasticity in the visual cortex. In order to investigate further the involvement of individual PKA subunits in visual cortical plasticity, LTP and LTD in vitro and ocular dominance plasticity in vivo in the developing visual cortex were examined in mice lacking the RII alpha subunit of PKA. Here we show that LTP in layers II/III was decreased in RII alpha knockout mice, but LTD was almost unaffected, and the ocular dominance shift induced by monocular deprivation was also partially blocked. These data provide evidence that RII alpha is involved in LTP and ocular dominance plasticity, and further suggest that different afferent inputs could selectively activate particular subunits of PKA and thereby direct specific aspects of visual cortical plasticity. |
| Databáze: | OpenAIRE |
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