Immunity in the Cervix: Interphase between Immune and Cervical Epithelial Cells
| Autor: | Jorgelina Barrios De Tomasi, Michael M. Opata, Chishimba Nathan Mowa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Chemokine Immunology Uterus Context (language use) Cervix Uteri Review Article 03 medical and health sciences 0302 clinical medicine Immune system Immunity Pregnancy medicine Immunology and Allergy Humans Cervix Menstrual Cycle Progesterone Immunity Cellular 030219 obstetrics & reproductive medicine Mucous Membrane biology Epithelial Cells Estrogens General Medicine Mucus Killer Cells Natural Postmenopause 030104 developmental biology medicine.anatomical_structure Vagina biology.protein Cytokines Female Menopause lcsh:RC581-607 Endocervix |
| Zdroj: | Journal of Immunology Research Journal of Immunology Research, Vol 2019 (2019) |
| ISSN: | 2314-7156 |
| Popis: | The cervix is divided into two morphologically and immunologically distinct regions, namely, (1) the microbe-laden ectocervix, which is proximal to the vagina, and (2) the “sterile” endocervix, which is distal to the uterus. The two cervical regions are bordered by the cervical transformation zone (CTZ), an area of changing cells, and are predominantly composed of cervical epithelial cells. Epithelial cells are known to play a crucial role in the initiation, maintenance, and regulation of innate and adaptive response in collaboration with immune cells in several tissue types, including the cervix, and their dysfunction can lead to a spectrum of clinical syndromes. For instance, epithelial cells block progression and neutralize or kill microorganisms through multiple ways. These (ways) include mounting physical (intercellular junctions, secretion of mucus) and immune barriers (pathogen-recognition receptor-mediated pathways), which collectively and ultimately lead to the release of specific chemokines and or cytokines. The cytokines subsequently recruit subsets of immune cells appropriate to a particular immune context and response, such as dendritic cells (DCs), T, B, and natural killer (NK) cells. The immune response, as most biological processes in the female reproductive tract (FRT), is mainly regulated by estrogen and progesterone and their (immune cells) responses vary during different physiological phases of reproduction, such as menstrual cycle, pregnancy, and post menopause. The purpose of the present review is to compare the immunological profile of the mucosae and immune cells in the ecto- and endocervix and their interphase during the different phases of female reproduction. |
| Databáze: | OpenAIRE |
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