Children with stable asthma have reduced airway matrix metalloproteinase-9 and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio
| Autor: | Michael D. Shields, Madeleine Ennis, S. V. Kamath, Liam G Heaney, Jeremy Lyons, Gary M. Doherty, Anthony Chisakuta, F. De Courcey, Sharon Christie |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Allergy Adolescent Neutrophils Immunology Inflammation Bronchi Cell Count Matrix metalloproteinase Gastroenterology Extracellular matrix Internal medicine Macrophages Alveolar Hypersensitivity Immunology and Allergy Medicine Humans Child Asthma Tissue Inhibitor of Metalloproteinase-1 medicine.diagnostic_test business.industry Respiratory disease Infant Epithelial Cells Tissue inhibitor of metalloproteinase medicine.disease respiratory tract diseases Bronchoalveolar lavage Matrix Metalloproteinase 8 Matrix Metalloproteinase 9 Case-Control Studies Child Preschool Chronic Disease Female medicine.symptom business Bronchoalveolar Lavage Fluid |
| Zdroj: | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 35(9) |
| ISSN: | 0954-7894 |
| Popis: | Summary Background Childhood asthma is characterized by inflammation of the airways. Structural changes of the airway wall may also be seen in some children early in the course of the disease. Matrix metalloproteinases (MMPs) are key mediators in the metabolism of the extracellular matrix (ECM). Objective To investigate the balance of MMP-8, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 in the airways of children with asthma. Methods One hundred and twenty-four children undergoing elective surgical procedures also underwent non-bronchoscopic bronchoalveolar lavage (BAL). MMP-8, MMP-9 and TIMP-1 were measured by ELISA. Results There was a significant reduction in MMP-9 in atopic asthmatic children (n=31) compared with normal children (n=30) [median difference: 0.57 ng/mL (95% confidence interval: 0.18–1.1 ng/mL)]. The ratio of MMP-9 to TIMP-1 was also reduced in asthmatic children. Levels of all three proteins were significantly correlated to each other and to the relative proportions of particular inflammatory cells in BAL fluid (BALF). Both MMP-8 and MMP-9 were moderately strongly correlated to the percentage neutrophil count (r=0.40 and 0.47, respectively, P |
| Databáze: | OpenAIRE |
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