Formulation and Evaluation of Sol-Gel Drug Delivery System for Intracanal pH Sensitive Controlled Delivery of Chlorhexidine
| Autor: | Pratik Verma, Harsimran Kaur, Radha Srikrishna Maganti, K S Vinod, Kapil Gandhi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Drug
media_common.quotation_subject Clinical Biochemistry Excipient lcsh:Medicine 02 engineering and technology Enterococcus faecalis intracanal medicament 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine endodontic failure enterococcus faecalis medicine Dentin Candida albicans media_common Chromatography biology business.industry Chlorhexidine lcsh:R 030206 dentistry General Medicine 021001 nanoscience & nanotechnology biology.organism_classification Dentistry Section medicine.anatomical_structure Drug delivery 0210 nano-technology business medicine.drug |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 11, Iss 4, Pp ZC68-ZC72 (2017) |
| Popis: | Introduction Persistence of viable micro-organisms even after thorough chemomechanical debridement has been cited as a major cause for endodontic failure. Chlorhexidine is a drug, which has shown marked efficacy against Enterococcus faecalis and Candida spp., which are mostly accounted for endodontic failure and it has demonstrated high degree of substantivity to dentin by adsorption. Another issue with chlorhexidine and other intracanal medicaments is the excessive or premature peaking of the drug leading to possible side effects. Aim The objective of this experimental work undertaken was to formulate a pH sensitive sol-gel sustained drug delivery system containing chlorhexidine. Materials and methods The formulations were prepared using different concentrations of GELRITE® (0.1% and 0.2%) and Chlorhexidine (0.1% and 0.2%). The prepared solutions were evaluated for pharmacological properties like sterility test, viscosity, drug content, drug release characteristics, drug excipient compatible study. Results The drug excipient compatibility studies showed no interaction between the excipient and the active constituent. The microbial analysis showed good efficacy against the test micro-organisms and Minimum Inhibitory Concentration (MIC) values against Candida albicans (ATCC® 14053™) was observed as 4 μl/ml for both formulation containing 0.1% and 0.2% of GELRITE® Gellan (polymer). Whereas, MIC values against Enterococcus faecalis was observed to be 3.2 μl/ml and 6 μl/ml for formulation containing 0.1% and 0.2% of GELRITE® Gellan (polymer) respectively. Conclusion From the present study, it could be successfully demonstrated that sol-gel formulations can be simple, easy to administer mode of intracanal drug delivery system. Localized pH changes present within the canal can trigger sol-gel conversion thereby releasing the drug in sustained manner with less toxicity and side effects. |
| Databáze: | OpenAIRE |
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