Preparation of high molecular weight radioiodinated alginic acid
| Autor: | P. Orlando, A. De Feo, R. Trenta, R. Trevisi, L. Binaglia, C. Melodia |
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| Rok vydání: | 1994 |
| Předmět: |
Schiff base
Chromatography Sodium cyanoborohydride Organic Chemistry chemistry.chemical_element Tyramine Iodine Biochemistry Analytical Chemistry chemistry.chemical_compound chemistry High specific activity Drug Discovery Organic chemistry Radiology Nuclear Medicine and imaging Spectroscopy Alginic acid |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 34:653-657 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580340709 |
| Popis: | A simple procedure is described for preparing125I-labelled alginic acid. The reducing terminal of alginic acid is derivatized with tyramine through the formation of Schiff base which is subsequently reduced with sodium cyanoborohydride. By radioiodination of the aromatic ring introduced,125I-labelled alginic acid was obtained with high specific activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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