Pseudohypoparathyroidism presenting as renal osteodystrophy
| Autor: | Ferris M. Hall, Margot Segall-Blank, Harry K. Genant, Felix O. Kolb, Lloyd E. Hawes |
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| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Pathology Bone disease Parathyroid hormone Disease Kidney Diagnosis Differential Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Renal osteodystrophy Femur Pelvic Bones Pseudohypoparathyroidism Chronic Kidney Disease-Mineral and Bone Disorder business.industry Kidney metabolism medicine.disease Hand Radiography Endocrinology Parathyroid Hormone Child Preschool Calcium Female Slipped capital femoral epiphysis business Epiphyses hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Skeletal radiology. 6(1) |
| ISSN: | 0364-2348 |
| Popis: | Pseudohypoparathyroidism (pseudo HPT) is the prototype of a group of diseases with end organ unresponsiveness to parathyroid hormone (PTH). Patients with the classic form of this disease have both renal and osseous resistance to PTH. We describe a rare variant of pseudo HPT with classic renal unresponsiveness to PTH but normal skeletal responsiveness to this hormone. The latter patients develop mentabolic bone disease in response to depressed calcium and elevated PTH levels. Skeletal abnormalities are histologically and radiologically indistinguishable from renal osteodystrophy and these patients frequently present in childhood with symptoms relating to slipped capital femoral epiphyses. The latter radiologic findings, in the face of normal renal function or the classic somatic features of the syndrome, are highly suggestive of pseudo HPT with normal skeletal responsiveness to PTH. |
| Databáze: | OpenAIRE |
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