Stereotactic body radiation therapy (SBRT) in the management of pulmonary spindle cell carcinoma
| Autor: | Saumil Gandhi, Ara A. Vaporciyan, Charles Lu, Moyosore D Awobajo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Image-Guided Biopsy
medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Pembrolizumab Radiography Interventional Radiosurgery Lesion 03 medical and health sciences 0302 clinical medicine Rare Disease Positron Emission Tomography Computed Tomography Biopsy medicine Humans Stage (cooking) Aged Lung medicine.diagnostic_test business.industry Carcinoma General Medicine medicine.disease Radiation therapy medicine.anatomical_structure Positron emission tomography 030220 oncology & carcinogenesis Female Radiology medicine.symptom business 030217 neurology & neurosurgery Spindle cell carcinoma |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | A 69-year-old woman underwent routine screening with CT scan of the chest, which showed a new right upper lobe lesion. Interval increase in size of the right upper lobe nodule over 3 months, prompted a CT-guided biopsy of the lung that confirmed a diagnosis of malignant pulmonary spindle cell carcinoma (PSCC) with 90% programmed death ligand 1 expression. Positron emission tomography CT demonstrated localised stage IIA disease. Given histologically proven PSCC and the rapid growth of her tumour, curative radiation with stereotactic body radiation therapy (SBRT) to the right upper lobe primary tumour was planned as patient was deemed not to be a surgical candidate. Repeat imaging with a CT chest 2 months after SBRT demonstrated good local control of the primary disease in the right upper lobe despite rapidly advancing distant metastasis. The patient continues systemic therapy with pembrolizumab, to which she has shown good response. |
| Databáze: | OpenAIRE |
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