Brain Mechanisms of Social Threat Effects on Working Memory
| Autor: | Edward E. Smith, Julie Spicer, Tor D. Wager, Vanessa A. van Ast, Sonja Schmer-Galunder, Israel Liberzon, James L. Abelson |
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| Přispěvatelé: | Klinische Psychologie (Psychologie, FMG) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Adolescent Hydrocortisone Cognitive Neuroscience Emotions Ventromedial prefrontal cortex Intraparietal sulcus Neuropsychological Tests Functional Laterality Cellular and Molecular Neuroscience Young Adult Neural Pathways medicine Image Processing Computer-Assisted Humans Attention Effects of sleep deprivation on cognitive performance Prefrontal cortex Saliva Social Behavior Cerebral Cortex Analysis of Variance Brain Mapping Working memory Cognition Articles Verbal Learning Magnetic Resonance Imaging Dorsolateral prefrontal cortex Oxygen medicine.anatomical_structure Memory Short-Term Female Consumer neuroscience Psychology Cognitive psychology |
| Zdroj: | Cerebral Cortex, 26(2), 544-556. Oxford University Press |
| ISSN: | 1460-2199 1047-3211 |
| Popis: | Social threat can have adverse effects on cognitive performance, but the brain mechanisms underlying its effects are poorly understood. We investigated the effects of social evaluative threat on working memory (WM), a core component of many important cognitive capabilities. Social threat impaired WM performance during an N-back task and produced widespread reductions in activation in lateral prefrontal cortex and intraparietal sulcus (IPS), among other regions. In addition, activity in frontal and parietal regions predicted WM performance, and mediation analyses identified regions in the bilateral IPS that mediated the performance-impairing effects of social threat. Social threat also decreased connectivity between the IPS and dorsolateral prefrontal cortex, while increasing connectivity between the IPS and the ventromedial prefrontal cortex, a region strongly implicated in the generation of autonomic and emotional responses. Finally, cortisol response to the stressor did not mediate WM impairment but was rather associated with protective effects. These results provide a basis for understanding interactions between social and cognitive processes at a neural systems level. |
| Databáze: | OpenAIRE |
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