Vaporized Cannabis differentially modulates sexual behavior of female rats according to the dose
| Autor: | Alejandra Mondino, Pablo Torterolo, María José Castro, Carlos García-Carnelli, Santiago Fernández, Atilio Falconi, Eleuterio Umpiérrez, Daniella Agrati |
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| Rok vydání: | 2019 |
| Předmět: |
Drug
Male Lordosis media_common.quotation_subject Clinical Biochemistry Physiology Stimulation Toxicology Affect (psychology) Biochemistry 03 medical and health sciences Behavioral Neuroscience Sexual Behavior Animal 0302 clinical medicine medicine Animals Cannabidiol Dronabinol Rats Wistar Reactivity (psychology) Social Behavior Biological Psychiatry media_common Cannabis Pharmacology Motivation biology Dose-Response Relationship Drug business.industry biology.organism_classification medicine.disease Endocannabinoid system 030227 psychiatry Rats Hallucinogens Female Volatilization business 030217 neurology & neurosurgery Locomotion medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 187 |
| ISSN: | 1873-5177 |
| Popis: | Studies exploring the effect of compounds that modulate the endocannabinoid system on sexual behavior have yielded contradictory results. However, the effect of smoked Cannabis in women has been consistently associated with an increase in sexual drive. Therefore, it can be speculated that vaporized Cannabis will augment sexually motivated components of the sexual behavior of female rats. To test this hypothesis, we compared the sexual behavior of late-proestrous female rats in a bilevel chamber after vaporizing 0, 200 or 400 mg of Cannabis flowers (containing 18% of delta-9-THC and undetectable levels of cannabidiol) during 10 min. We found that both doses of Cannabis increased the duration of the lordosis response, whereas the highest dose also reduced the lordosis quotient of females. The lowest dose of Cannabis augmented the display of hops and darts without altering the expression of sexual solicitations of females, while the highest one did not affect the expression of hops and darts but reduced sexual solicitations. These effects were not accompanied by alterations of females' ambulatory behavior. The increment of the duration of lordosis response produced by both doses of Cannabis could be associated to a general effect of this drug in sensory processing, as can be an enhancement of females' sensory reactivity to male's stimulation. However, the reduction in the display of solicitations and lordosis in response to mounting observed in females exposed to the highest dose when compared to control and 200 mg of Cannabis groups indicates a reduction of sexual receptivity and motivation. This differential effect of vaporized Cannabis according to the dose employed, suggests that it modulates sexual behavior in a complex way, impacting neural circuits that control different aspects of this social behavior. |
| Databáze: | OpenAIRE |
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