A laser flash photolysis study of di-, tri- and tetrafluorinated phenylnitrenes; implications for photoaffinity labeling
| Autor: | Matthew S. Platz, Karlyn A. Schnapp |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pharmacology
Azides Photolysis Photoaffinity labeling Lasers Spectrum Analysis Nitrene Aryl Organic Chemistry Biomedical Engineering Pharmaceutical Science Affinity Labels Bioengineering Fluorine Photochemistry chemistry.chemical_compound Reaction rate constant chemistry Pyridine Flash photolysis Singlet state Azide Biotechnology |
| Zdroj: | Bioconjugate Chemistry. 4:178-183 |
| ISSN: | 1520-4812 1043-1802 |
| DOI: | 10.1021/bc00020a011 |
| Popis: | Several fluorinated aryl azides (2,6 and 2,4-difluorophenyl azide, 2,4,6-triflurorophenyl azide, and methyl 4-azido-2,3,5,6-tetrafluorobenzoate) were studied by laser flash photolysis techniques. In each case, the azides from singlet nitrenes which can be intercepted with pyridine to form ylides. This allowed determination of the rate constant for ring expansion of the singlet nitrene to the dehydroazepine and measurement of the absolute rate constants for reaction of the singlet nitrenes with typical quenchers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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