Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer
| Autor: | Ronald Ghossein, Jeffrey A. Knauf, Mabel Ryder, Julio C. Ricarte-Filho, James A. Fagin |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Article Immunoenzyme Techniques Young Adult Endocrinology stomatognathic system medicine Carcinoma Humans Neoplasm Invasiveness Thyroid Neoplasms skin and connective tissue diseases Survival rate Thyroid cancer Aged Neoplasm Staging Aged 80 and over Tissue microarray business.industry CD68 Macrophages Thyroid Cancer Cell Differentiation Middle Aged medicine.disease Survival Rate medicine.anatomical_structure Oncology Tissue Array Analysis Tumor progression Cancer research Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine Related Cancer. 15:1069-1074 |
| ISSN: | 1479-6821 1351-0088 |
| Popis: | Thyroid cancers are infiltrated with tumor-associated macrophages (TAMs), yet their role in cancer progression is not known. The objectives of this study were to characterize the density of TAMs in well-differentiated (WDTC), poorly differentiated (PDTC), and anaplastic thyroid cancers (ATC) and to correlate TAM density with clinicopathologic parameters. Immunohistochemistry was performed on tissue microarray sections from WDTC (n=33), PDTC (n=37), and ATC (n=20) using macrophage-specific markers. Electronic medical records were used to gather clinical and pathologic data. Follow-up information of PDTC patients was available for 0-12 years. In total, 9 out of 33 WDTC (27%), 20 out of 37 PDTC (54%), and 19 out of 20 ATC (95%) had an increased density of CD68(+) TAMs (> or = 10 per 0.28 mm(2); WDTC versus PDTC, P=0.03; WDTC versus ATC, P |
| Databáze: | OpenAIRE |
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