Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle?

Autor: Maryse Etienne-Julan, Vanessa Tarer, Marie-Dominique Hardy-Dessources, Marie Laure Lalanne-Mistrih, Benoit Tressières, Danièle Mougenel, Philippe Connes, Yann Lamarre, Nathalie Lemonne, Olivier Hue, Xavier Waltz
Přispěvatelé: Adaptations au Climat Tropical, Exercice et Santé (ACTES), Université des Antilles et de la Guyane (UAG), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratory of Excellence GR-Ex 'The red cell: from genesis to death', PRES Sorbonne Paris Cité, Protéines de la membrane érythrocytaire et homologues non-érythroides, Université des Antilles et de la Guyane (UAG)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane, Adaptation, Climat Tropical, Exercice et Santé (ACTES), Université des Antilles (UA), Université des Antilles (Pôle Guadeloupe), Unité Transversale de la Drépanocytose, CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Hôpital Ricou, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Clinical Hemorheology and Microcirculation
Clinical Hemorheology and Microcirculation, IOS Press, 2015, 59, pp.37-43. ⟨10.3233/CH-131742⟩
Clinical Hemorheology and Microcirculation, IOS Press, 2018, pp.37-43. ⟨10.3233/CH-131742⟩
ISSN: 1386-0291
Popis: International audience; The hematocrit-to-viscosity ratio (HVR) has been widely used has an estimate of red blood cell (RBC) oxygen transport effectiveness into the microvasculature or as an oxygen delivery index. However, no study investigated the possibility of HVR to truly reflect RBC oxygen transport effectiveness or to be an oxygen delivery index. We measured blood viscosity at high shear rate (225 s −1), hematocrit, HVR, as well as the microvascular oxyhemoglobin saturation (TOI; tissue oxygen index) by spatial resolved near-infrared spectroscopy (NIRS) at cerebral and muscle levels in three population known to have various degrees of hemorheological abnormalities: healthy subjects (AA), patients with sickle cell SC disease (SC) characterized by moderate anemia and patients with sickle cell anemia (SS) marked by severe anemia. At both the cerebral and muscle level, HVR was positively correlated with TOI (r = 0.28; p = 0.03 and r = 0.38; p = 0.003, at the cerebral and muscle level, respectively). These findings suggest that HVR probably play a key role in blood flow and hemodynamic regulation in the microvasculature, hence modulating the amount of oxygen available for tissues. Nevertheless, the strengths of the associations are weak (R 2 < 0.50), suggesting that other determinants modulate microvascular blood flow and oxygenation, such as vascular geometry and vasomotor reserve.
Databáze: OpenAIRE
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