Enhancement of the Antifungal Activity of Rapamycin by the Coproduced Elaiophylin and Nigericin
| Autor: | Aiqi Fang, Grace K. Wong, Arnold L. Demain |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
endocrine system
Antifungal Agents Nigericin Microbial Sensitivity Tests Inhibitory Concentration 50 chemistry.chemical_compound Minimum inhibitory concentration Candida albicans Drug Discovery Sirolimus Pharmacology Dose-Response Relationship Drug biology Streptomycetaceae biology.organism_classification In vitro Corpus albicans Anti-Bacterial Agents Biochemistry chemistry Drug Therapy Combination Macrolides Actinomycetales Streptomyces hygroscopicus |
| Zdroj: | The Journal of Antibiotics. 53:158-162 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and nigericin. Although elaiophylin has no activity against Candida albicans ATCC 11651, it markedly enhances rapamycin's antifungal activity. Nigericin has only weak activity on its own but it also enhances rapamycin action. Surprisingly, elaiophylin does not enhance nigericin activity on C. albicans. |
| Databáze: | OpenAIRE |
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