Current understanding of the Trypanosoma cruzi-cardiomyocyte interaction
| Autor: | Tatiana G. Melo, Claudia M. Calvet, Mirian Claudia de Souza Pereira, Luciana Ribeiro Garzoni, Dayse T. Silva Neto, L. Meirelles, Francisco Odêncio Rodrigues de Oliveira, N S L Maria |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Chagas disease
lcsh:Immunologic diseases. Allergy extracellular matrix Trypanosoma cruzi Immunology cardiomyocyte Clinical manifestation Disease Pathogenesis Mini Review Article parasitic diseases medicine Immunology and Allergy cell recognition Cytoskeleton biology Mechanism (biology) apoptosis medicine.disease biology.organism_classification Endocytosis cell junction Molecular Response lcsh:RC581-607 Intracellular |
| Zdroj: | Frontiers in Immunology, Vol 3 (2012) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| Popis: | Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits multiple strategies to ensure its establishment and persistence in the host. Although this parasite has the ability to infect different organs, heart impairment is the most frequent clinical manifestation of the disease. Advances in knowledge of T. cruzi-cardiomyocyte interactions have contributed to a better understanding of the biological events involved in the pathogenesis of Chagas disease. This brief review focuses on the current understanding of molecules involved in T. cruzi-cardiomyocyte recognition, the mechanism of invasion, and on the effect of intracellular development of T. cruzi on the structural organization and molecular response of the target cell. |
| Databáze: | OpenAIRE |
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