What is Asthma? Pathophysiology, Demographics, and Health Care Costs
| Autor: | Jonathan Maslan, James W. Mims |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Global Health Immunoglobulin E Risk Assessment Severity of Illness Index Recurrence Epidemiology medicine Humans Eosinophilia Anti-Asthmatic Agents Leukocytosis Asthma biology business.industry Airway Resistance Health Care Costs General Medicine Mast cell medicine.disease Pathophysiology Respiratory Function Tests respiratory tract diseases Airway Obstruction medicine.anatomical_structure Otorhinolaryngology Immunology biology.protein Female Radiography Thoracic Cytokine secretion Bronchial Hyperreactivity Inflammation Mediators medicine.symptom Environmental Pollution business |
| Zdroj: | Otolaryngologic Clinics of North America. 47:13-22 |
| ISSN: | 0030-6665 |
| DOI: | 10.1016/j.otc.2013.09.010 |
| Popis: | Asthma is an obstructive pulmonary disorder with exacerbations characterized by symptoms of shortness of breath, cough, chest tightness, and/or wheezing. Symptoms are caused by chronic airway inflammation. There are multiple cell types and inflammatory mediators involved in its pathophysiology. The airway inflammation is frequently mediated by Th2 lymphocytes, whose cytokine secretion leads to mast cell stimulation, eosinophilia, leukocytosis, and enhanced B-cell IgE production. Although various genes have been identified as likely contributors to asthma development, asthma is largely environmentally triggered and has a multifactorial cause. Asthma is extremely common, especially in poor, urban environments. Asthma is the third most common reason for pediatric hospitalizations. |
| Databáze: | OpenAIRE |
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