Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma
| Autor: | Jayasingham Jayamohan, Hanh Vu, Sarah Leeson, Puma Sundaresan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment R895-920 radiation therapy 030218 nuclear medicine & medical imaging 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine Ocular Adnexal MALT lymphoma Orbital radiotherapy Medicine Humans Radiology Nuclear Medicine and imaging non‐Hodgkin Lymphoma MALT lymphoma Aged Retrospective Studies Aged 80 and over POAML Radiological and Ultrasound Technology Performance status business.industry Eye Neoplasms Distant relapse Dose fractionation Lymphoma B-Cell Marginal Zone Original Articles Middle Aged medicine.disease Radiation therapy Regimen Lymphatic system 030220 oncology & carcinogenesis Female Original Article Radiology Dose Fractionation Radiation business |
| Zdroj: | Journal of Medical Radiation Sciences, Vol 68, Iss 3, Pp 269-273 (2021) Journal of Medical Radiation Sciences |
| ISSN: | 2051-3895 2051-3909 |
| Popis: | Introduction Most primary ocular adnexal lymphomas are those involving mucosa‐associated lymphoid tissue (MALT). Radiotherapy (RT) dose regimens in the literature vary from the historically used high doses (up to 56 Gy) to lower dose RT. We aimed to examine our institution’s experience with the use of orbital RT for treating early‐stage primary ocular adnexal MALT lymphoma (POAML). Methods Patients treated for stage I or II POAML over a 12‐year period (July 2006 to June 2018) were identified through institutional databases. Data were retrospectively collated through review of patient records. Descriptive statistical methods were employed to analyse the data. Results Eighteen patients (median age of 67; range 44‐87yrs) with localised POAML (3 cases of bilateral disease) were identified, resulting in a total of 21 evaluable orbits. Eight (44%) patients were female, and all were documented to be of good performance status (ECOG 0‐1). The median follow‐up was 34 months (range 8‐75 months). The commonest dose fractionation used was 20 Gy in 10 fractions (n = 13 orbits) and a 3D conformal or volumetric modulated arc therapy (VMAT) technique was used in the majority of cases. None of the patients experienced an in‐field recurrence. One patient had experienced a contralateral orbital recurrence two years post‐unilateral orbital RT for orbital MALT lymphoma. Three patients experienced distant relapse. Conclusion The use of lower dose orbital RT such as 20 Gy in 10 fractions (or radio biologically equivalent) yields excellent local disease control in the management of ocular adnexal MALT lymphoma. The durability of the response appears to be favourable. Given the indolent nature of the disease and the low levels of toxicity associated with lower dose orbital RT, this regimen remains our favoured approach to the management of localised POAML. We aimed to examine our institution’s experience with the use of orbital RT for treating early‐stage primary ocular adnexal MALT lymphoma (POAML).The use of lower dose orbital RT such as 20 Gy in 10 fractions (or radio biologically equivalent) yields excellent local disease control in the management of ocular adnexal MALT lymphoma. |
| Databáze: | OpenAIRE |
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