Natural Human Antibody Responses to Plasmodium vivax Apical Membrane Antigen 1 under Low Transmission and Unstable Malaria Conditions in Sri Lanka
| Autor: | P.H. Premaratne, Thilan Wickramarachchi, Preethi V. Udagama-Randeniya, Alan W. Thomas, Clemens H. M. Kocken, K. L. R. Lakshman Perera, Sumith Bandara, Shiroma M. Handunnetti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Immunology
Plasmodium vivax Protozoan Proteins Antibodies Protozoan Antigens Protozoan Microbiology Immunoglobulin G Antigen parasitic diseases medicine Malaria Vivax Animals Humans Apical membrane antigen 1 Sri Lanka biology Malaria vaccine Membrane Proteins biology.organism_classification medicine.disease Isotype Virology Infectious Diseases Microbial Immunity and Vaccines biology.protein Parasitology Antibody Malaria |
| Popis: | Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemic. A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in residents from areas of endemicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|