Activation of whole body by high levels of polyamine intake in rats
| Autor: | Naohiro Sata, Takumi Teratani, Tetsuo Ijichi, Fujimoto Yasuhiro, Yasunaru Sakuma, Naoya Kasahara, Joji Kitayama |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Polyamine Aging Programmed cell death medicine.medical_specialty Living imaging Clinical Biochemistry Mice Transgenic Body weight Biochemistry chemistry.chemical_compound Internal medicine Oral intake Polyamines medicine Animals Humans Liver damage Chemistry Organic Chemistry Biological Transport Anti-aging Geroscience Rats Transgenic rat Endocrinology Liver Rats Inbred Lew Cytoplasm Original Article Whole body Homeostasis |
| Zdroj: | Amino Acids |
| ISSN: | 1438-2199 0939-4451 |
| Popis: | Polyamines are important to the survival and activation of organs and tissues via a homeostatic cell-metabolic process, and the polyamine content in cytoplasm decreases with aging. Decreases in cellular polyamine have been known to augment mutagenesis and cell death. Thus, supplementary polyamine in food is important to the prevention of aging. Here we show the anti-aging effects of oral intake of polyamine using luciferase-transgenic rats. Healthy rats, 10–12 weeks old, were given foods containing 0.01% and 0.1% (w/w) of polyamine, as compared a control food without polyamine, for 4 weeks. Using a bioimaging system, the photon intensities seen in the whole bodies and livers of rats consuming 0.1% of polyamine in food were stronger than those in rats consuming 0.01% and 0% of polyamine. However, there were no differences between groups in other characteristics, such as liver damage and body weight. In conclusion, we found that polyamine intake can activate cells throughout the whole body, providing an anti-aging effect. Supplementary Information The online version contains supplementary material available at 10.1007/s00726-021-03079-4. |
| Databáze: | OpenAIRE |
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